Polymerized fibrin activates glycoprotein VI
نویسندگان
چکیده
منابع مشابه
Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation.
Fibrin, the coagulation end product, consolidates the platelet plug at sites of vascular injury and supports the recruitment of circulating platelets. In addition to integrin αIIbβ3, another as-yet-unidentified receptor is thought to mediate platelet interaction with fibrin. Platelet glycoprotein VI (GPVI) interacts with collagen and several other adhesive macromolecules. We evaluated the hypot...
متن کاملThe snake venom toxin alboaggregin-A activates glycoprotein VI.
The glycoprotein (GP)-Ib-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor gamma-chain. The evidence for this was based in part on studies with the GPIbalpha-selective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has act...
متن کاملAlboaggregin A activates platelets by a mechanism involving glycoprotein VI as well as glycoprotein Ib.
The snake venom C-type lectin alboaggregin A (or 50-kd alboaggregin) from Trimeresurus albolabris was previously shown to be a platelet glycoprotein (GP) Ib agonist. However, investigations of the signal transduction induced in platelets showed patterns of tyrosine phosphorylation that were different from those of other GPIb agonists and suggested the presence of an additional receptor. In this...
متن کاملBrief report The snake venom toxin alboaggregin-A activates glycoprotein VI
The glycoprotein (GP)–Ib-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor g-chain. The evidence for this was based in part on studies with the GPIbaselective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has activity at ...
متن کاملFocusing on plasma glycoprotein VI.
New methods for analysing both platelet and plasma forms of the platelet-specific collagen receptor, glycoprotein VI (GPVI) in experimental models or human clinical samples, and the development of the first therapeutic compounds based on dimeric soluble GPVI-Fc or anti-GPVI antibody-based constructs, coincide with increased understanding of the potential pathophysiological role of GPVI ligand b...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2015-06-646711